The flavonoid Baicalein attenuates cuprizone-induced demyelination via suppression of neuroinflammation
نویسندگان
چکیده
منابع مشابه
Flavonoid baicalein attenuates activation-induced cell death of brain microglia.
Baicalein (5,6,7-trihydroxyflavone), a flavonoid originated from the root of Chinese medicinal herb Scutellaria baicalensis, has been shown to exert anti-inflammatory and antioxidant effects, and it is a well known inhibitor of 12-lipoxygenase. We have previously reported that neuroglia undergo nitric oxide (NO)-dependent and NO-independent apoptosis upon inflammatory activation. In the current...
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Growth arrest-specific protein 6 (gas6) activities are mediated through the Tyro3, Axl, and Mer family of receptor tyrosine kinases. Gas6 is expressed and secreted by a wide variety of cell types, including cells of the central nervous system (CNS). In this study, we tested the hypothesis that administration of recombinant human Gas6 (rhGas6) protein into the CNS improves recovery following cup...
متن کاملProtective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum
Objective(s): Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. Materials and Methods: Adult male C57BL/6J mice were fed a chow containing 0.2 % cuprizone for 6 ...
متن کاملAn Alternative Cuprizone-Induced Demyelination and Remyelination Mouse Model
The cuprizone model is a well-established and investigated paradigm to study demyelination and remyelination in rodents. Cuprizone is usually administrated by mixing in the powdered or pelleted rodent chow. However, since cuprizone is sensitive to the environment and the consumption of it varies between different animals, the major issue is the discrepancy in demyelination of the animals. This ...
متن کاملCuprizone-induced demyelination in Wistar rats; electrophysiological and histological assessment.
OBJECTIVES Multiple Sclerosis (MS) is a disease that affects the Central Nervous System by destructing myelin shield and also can affects the peripheral nervous system. Demyelination is acquired characteristics disease and appears with the degeneration of myelin which protects the axons. Cuprizone (CPZ) model is a toxic demyelination model. The purpose of this study was to develop an MS model b...
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ژورنال
عنوان ژورنال: Brain Research Bulletin
سال: 2017
ISSN: 0361-9230
DOI: 10.1016/j.brainresbull.2017.09.007